Complete integrated line for ampoules consisting of washing, sterilizing tunnel, filling, sealing, Inspection and labelling, Aseptic filling machine, Competitive price of quality filling equipment. Custom and optimized solutions, Servo control system, 21 CFR Part 11 compliance /GAMP/ SCADA system, Ampoule and Vial Washing Drying Filling Production Line. Ampoule Filling Line & Combo Ampoule offers compact machines.
Ampoule Filling Line & Combo compact Glass Ampoule Filling line
Ampoule Filling Line & Combo
Operation of Ampoule filling line
The Combi Ampoule line model ampoule washing-drying-filling-sealing production line is composed of the QCL series vertical ultrasonic Ampoule washing machine, ASMR tunnel hot air circulation sterilizing oven and AGF series vertical filling-sealing machine, whilst the three component machines can also be used independently. Suitable for production of ampoules of 1-20ml, it can complete more than 20 pharmaceutical procedures such as spray and water filling, ultrasonic rough washing, Ampoule exterior wall washing, Ampoule interior wall continuous twice circulation water washing, primary blowing, primary fresh water washing, continuous twice blowing, Ampoule exterior wall blowing, preheating, drying, sterilizing, pyroxene removing, cooling, front gas charging, filling, rear gas charging, preheating, sealing, and etc. The production line is a new-type line which is researched and developed by us after years of efforts through integrating our proprietary patented technologies on the basis of digesting and absorbing advanced domestic and overseas technologies.
The whole line adopts PLC main control, frequency converter and touch screen control technology whilst the production process is stable and reliable. The touch screen can display running dynamics of each single machine, water pressure, air pressure, wind pressure and temperature at each control point. The display of each on-off status and faults, fault self-diagnosis, fault analysis and eliminating methods realizes automatic control during the whole production. The production line is provided with the three-machine automatically control and balancing device to ensure the balanced and reliable production.
Ampoule Filling Line & Combo Ampoule
Features of Ampoule filling line
◆ The Ampoule washing machine adopts mechanical hands to clamp the bottles, suitable for ampoules of 1-20ml;
◆ The water-gas spray needles adopt the reciprocating tracking insertion method for Ampoule washing, featured by excellent washing effect and energy saving. It is also provided with a device that prevents the needle holder from shaking to enhance the accuracy of the spray needle’s insertion into the Ampoule and reduce the occurrence of needle breakage;
◆ The water and gas pipes are totally separable from the spray needles, so that cross contamination is avoided and GMP requirements are satisfied;
◆ The buffer block is installed before the Ampoule feeding screw of the Ampoule washing machine to protect the screw and reduce Ampoule breakage;
◆ Ampoule discharging is realized by the integral imported synchronous belt that is connected to the Ampoule pushing block to convey ampoules , a structure that ensures stable and reliable operation ;
◆ The oven adopts hot air circulation heating to achieve even temperature and energy saving;
◆ The oven is provided with the function of protecting against sudden power-off to ensure safe running;
◆ The oven can be equipped with the circulation water cooling device that does not consume wind volume in the room, whilst reducing the risk of unbalanced differential pressure in the room and achieving good cooling effect;
◆ The oven can be equipped with the differential pressure automatic balancing and regulating system to reduce the problems of deviation at the high temperature section caused by unbalanced differential pressure in the room and oven, temperature rise in the filling room, washing and drying room, and etc;
◆ The oven is provided with DOP inspection ports (including inspection ports for wind pressure, wind speed and dust particles);
◆ The cooling section in the oven can be provided with the sterilization function (selective for FDA);
◆ The oven mesh belt can be equipped with the ultrasonic and CIP cleaning systems;
◆ The oven cavity can be subject to all-round, multi-angled high pressure water washing;
◆ In the vertical filling-sealing machine, Ampoule feeding is carried out by using the constant speed pushing wheel instead of the sector pushing block to reduce the bottles’ breakage rate;
◆ The filling-sealing machine adopts the imported synchronous belt and Ampoule turning gearbox instead of the old-fashioned Ampoule turning box, featured by low wear rate and reliable operation;
◆ The filling-sealing machine is equipped with the needle holder and clamping stand automatic locking device;
◆ The filling-sealing machine can be equipped with the ceramic pump, stainless steel pump and peristaltic pump;
◆ The filling-sealing machine can be equipped with the servo filling system.
Combi Ampoule and Vial Filling Machine
Optional Add-on
According to customers’ requirements, the production line can also be equipped with the following:
◆ Control system of such brands as Siemens, Schneider, Mitsubishi, Delta, and etc;
◆ Water pressure, air pressure, water temperature, ultrasonic strength, dust particles and wind speed online inspection, alarming, recording and printing systems;
◆ ORABS, CRABS, aseptic isolator system.
Ampoule And Vial Washing-Drying-Filling Production Line
Technical Parameters
Product Model | AGF8/1-20 | AGF10/1-20 | AGF12/1-10 | AGFD12/1-20 | AGF16/1-5 |
Applicable specifications(ml) | 1-20ml (GB standard ampoule) | 1-20ml (GB standard ampoule) | 1-10ml (GB standard ampoule) | 1-20ml (GB standard ampoule) | 1-5ml (GB standard ampoule) |
Capacity(pcs/h) | 1-2ml: 22,000 5ml: 16,000 10ml: 11,000 20ml: 6,000 |
1-2ml: 24,000 5ml: 18000 10ml: 15,000 20ml: 8,000 |
1-2ml: 28,000-30,000 5ml: 20,000 |
1-2ml: 12,000-30,000 | 1-5ml: 38,000-40,000 |
Cleanness(%) | > 99 | > 99 | > 99 | > 99 | > 99 |
Qualified rate(%) | ≥ 99 (standard solution) | ≥ 99 (standard solution) | ≥ 99 (standard solution) | ≥ 99 (standard solution) | ≥ 99 (standard solution) |
Filling accuracy(%) | ≤ ±2.5 | ≤ ±2.5 | ≤ ±2.5 | ≤ ±2.5 | ≤ ±2.5 |
Fresh water consumption and pressure | Consumption:0.4-1.0cbm/h Pressure: 0.2mpa |
Consumption:0.4-1.0cbm/h Pressure: 0.2mpa |
Consumption:0.4-1.0cbm/h Pressure: 0.2mpa |
Consumption:0.4-1.0cbm/h Pressure: 0.2mpa |
Consumption:0.4-1.0cbm/h Pressure: 0.2mpa |
Purified compressed air consumption and pressure | Consumption:30-75cbm/h Pressure: 0.15mpa |
Consumption:30-75cbm/h Pressure: 0.15mpa |
Consumption:30-75cbm/h Pressure: 0.15mpa |
Consumption:30-75cbm/h Pressure: 0.15mpa |
Consumption:30-75cbm/h Pressure: 0.15mpa |
Sterilizing temperature(°C) | 300-350 | 300-350 | 300-350 | 300-350 | 300-350 |
Exhaust volume(m3/h) | 4100 | 4100 | 4100 | 4100 | 4100 |
Gas fuel consumption and pressure | Consumption: 1.5-2.5cbm/h Pressure: 0.2-0.3mpa |
Consumption: 1.5-2.5cbm/h Pressure: 0.2-0.3mpa |
Consumption: 1.5-2.5cbm/h Pressure: 0.2-0.3mpa |
Consumption: 1.5-2.5cbm/h Pressure: 0.2-0.3mpa |
Consumption: 1.5-2.5cbm/h Pressure: 0.2-0.3mpa |
Oxygen consumption and pressure | Consumption: 1.2-1.5cbm/h Pressure: 0.2-0.3mpa |
Consumption: 1.2-1.5cbm/h Pressure: 0.2-0.3mpa |
Consumption: 1.2-1.5cbm/h Pressure: 0.2-0.3mpa |
Consumption: 1.2-1.5cbm/h Pressure: 0.2-0.3mpa |
Consumption: 1.2-1.5cbm/h Pressure: 0.2-0.3mpa |
Overall dimensions(LxWxH) (mm) | 9940 × 2003 × 2445 | 10100 × 2260 × 2455 | 10100 × 2260 × 2455 | 10100 × 2260 × 2455 | 10600 × 2260 × 2455 |
Weight(kg) | 7500 | 7500 | 7500 | 7500 | 7500 |
Power capacity | 380V50hz, 71kw | 380V50hz, 71kw | 380V50hz, 71kw | 380V50hz, 71kw | 380V50hz, 71kw |
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The Glass Ampoule Filling Sealing Machine has been assembled based on the most tried and tested module and principle of slant travelling of ampoules during the filling and sealing of ampoules through the Ampoule Filling Machine. This is done to ensure that the maximum amount of optimization of resources is done for filling and sealing of all types of ampoules that vary from each other in terms of dimensions, thickness and or any other variation.
The Six Head Ampoule Filling Sealing Machine has six heads and like others machines in its family, it is also manufactured based on the principle of slant travelling of ampoules during the process of filling and sealing of ampoules. This principle has been essentially adopted taking into consideration the vast number of variations in thickness, dimensions and sizes of different ampoules available.
The Four Head Ampoule Filling Machine has been made on the basis of one of the most reliable and proven principles of machines i.e. slant travelling of ampoules during the process of sealing and filling of ampoules which is also considered as the most optimizable and scalable solutions. This process has also been adopted since it takes care of a diverse variety of ampoules which differ from each other on the basis of thickness, dimensions or material.
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